- Burillo J, Fernández-Rhodes M, Piquero M, López-Alvarado P, Menéndez JC, Jiménez B, González-Blanco C, Marqués P, Guillén C, Benito M. Human amylin aggregates release within exosomes as a protective mechanism in pancreatic β cells: Pancreatic β-hippocampal cell communication. Biochimica et Biophysica Acta- Mol Cell Res 1868(5): 118971, 2021, Apr.
- Burillo J, Marqués P, Jiménez B, González-Blanco C, Benito M, Guillén C. Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease. Cells. 10(5): 1236, 2021, May 18.
- Specific knockout of p85α in brown adipose tissue induces resistance to high-fat diet-induced obesity and its metabolic complications in male mice. Gomez-Hernandez A, Lopez-Pastor AR, Rubio-Longas C, Majewski P, Beneit N, Viana-Huete V, García-Gómez G, Fernandez S, Hribal ML, Sesti G, Escribano O, Benito M. Mol Metab. 2020 Jan;31:1-13. doi: 10.1016/j.molmet.2019.10.010. Epub 2019 Nov 9.
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Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status.
Marqués P, Kamitz A, Bartolomé A, Burillo J, Martínez H, Jiménez B, Fernández-Rhodes M, Guillén C, Benito M.
Cell Death Discov. 2019 Sep 30;5:138. doi: 10.1038/s41420-019-0219-x. eCollection 2019.
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Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity. Lopez-Pastor AR, Gomez-Hernandez A, Diaz-Castroverde S, Gonzalez-Aseguinolaza G, Gonzalez-Rodriguez A, Garcia G, Fernandez S, Escribano O, Benito M. Dis Model Mech. 2019 Feb 7;12(2). pii: dmm036186. doi: 10.1242/dmm.036186.
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Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. Guerra C, Navarro P, Valverde AM, Arribas M, Brüning J, Kozak LP, Kahn CR, Benito M. J Clin Invest. 2019 Jan 2;129(1):437. doi: 10.1172/JCI126191. Epub 2019 Jan 2. No abstract available.
- Chronic Exercise Improves Mitochondrial Function and Insulin Sensitivity in Brown Adipose Tissue. De Las Heras N, Klett-Mingo M, Ballesteros S, Martín-Fernández B, Escribano Ó, Blanco-Rivero J, Balfagón G, Hribal ML, Benito M, Lahera V, Gómez-Hernández A. Front Physiol. 2018 Aug 17;9:1122. doi: 10.3389/fphys.2018.01122. eCollection 2018.
- Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics. Hernández MG, Aguilar AG, Burillo J, Oca RG, Manca MA, Novials A, Alcarraz-Vizan G, Guillén C, Benito M. Cell Death Dis. 2018 May 1;9(5):481. doi: 10.1038/s41419-018-0533-x.
- Potential role of insulin receptor isoforms and IGF receptors in plaque instability of human and experimental atherosclerosis. Beneit N, Martín-Ventura JL, Rubio-Longás C, Escribano Ó, García-Gómez G, Fernández S, Sesti G, Hribal ML, Egido J, Gómez-Hernández A, Benito M. Cardiovasc Diabetol. 2018 Feb 20;17(1):31. doi: 10.1186/s12933-018-0675-2.
- Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity.
Viana-Huete V, Guillén C, García G, Fernández S, García-Aguilar A, Kahn CR, Benito M.
Endocrinology. 2018 Jan 1;159(1):323-340. doi: 10.1210/en.2017-00738.
- MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling.
Bartolomé A, García-Aguilar A, Asahara SI, Kido Y, Guillén C, Pajvani UB, Benito M.
Mol Cell Biol. 2017 Nov 13;37(23). pii: e00441-17. doi: 10.1128/MCB.00441-17. Print 2017 Dec 1.
- Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis.
Beneit N, Fernández-García CE, Martín-Ventura JL, Perdomo L, Escribano Ó, Michel JB, García-Gómez G, Fernández S, Díaz-Castroverde S, Egido J, Gómez-Hernández A, Benito M.
Cardiovasc Diabetol. 2016 Dec 1;15(1):161.
- Prevalent role of the insulin receptor isoform A in the regulation of hepatic glycogen metabolism in hepatocytes and in mice.
Diaz-Castroverde S, Baos S, Luque M, Di Scala M, González-Aseguinolaza G, Gómez-Hernández A, Beneit N, Escribano O, Benito M.
Diabetologia. 2016 Dec;59(12):2702-2710. Epub 2016 Sep 7.
- Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice.
Diaz-Castroverde S, Gómez-Hernández A, Fernández S, García-Gómez G, Di Scala M, González-Aseguinolaza G, Fernández-Millán E, González-Rodríguez Á, García-Bravo M, Chambon P, Álvarez C, Perdomo L, Beneit N, Escribano O, Benito M.
Dis Model Mech. 2016 Nov 1;9(11):1271-1281. Epub 2016 Aug 24.
- TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy.
García-Aguilar A, Guillén C, Nellist M, Bartolomé A, Benito M.
Biochim Biophys Acta. 2016 Nov;1863(11):2658-2667. doi: 10.1016/j.bbamcr.2016.08.006. Epub 2016 Aug 16.
- Severe Brown Fat Lipoatrophy Aggravates Atherosclerotic Process in Male Mice.
Gómez-Hernández A, Beneit N, Escribano Ó, Díaz-Castroverde S, García-Gómez G, Fernández S, Benito M.
Endocrinology. 2016 Sep;157(9):3517-28. doi: 10.1210/en.2016-1148. Epub 2016 Jul 14
- Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity.
Viana-Huete V, Guillén C, García-Aguilar A, García G, Fernández S, Kahn CR, Benito M.
Endocrinology. 2016 Apr;157(4):1495-511. doi: 10.1210/en.2015-1623. Epub 2016 Feb 24.
- Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process.
Perdomo L, Beneit N, Otero YF, Escribano Ó, Díaz-Castroverde S, Gómez-Hernández A, Benito M.
Cardiovasc Diabetol. 2015 Jun 10;14:75. doi: 10.1186/s12933-015-0237-9.
- Insulin receptor isoform A confers a higher proliferative capability to pancreatic beta cells enabling glucose availability and IGF-I signaling.
Escribano O, Gómez-Hernández A, Díaz-Castroverde S, Nevado C, García G, Otero YF, Perdomo L, Beneit N, Benito M.
Mol Cell Endocrinol. 2015 Jul 5;409:82-91. doi: 10.1016/j.mce.2015.03.008. Epub 2015 Mar 19.
- Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage.
Gómez-Hernández A, Perdomo L, de las Heras N, Beneit N, Escribano O, Otero YF, Guillén C, Díaz-Castroverde S, Gozalbo-López B, Cachofeiro V, Lahera V, Benito M.
Cardiovasc Diabetol. 2014 Jul 31;13:108. doi: 10.1186/s12933-014-0108-9.
- Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment.
Bartolomé A, Kimura-Koyanagi M, Asahara S, Guillén C, Inoue H, Teruyama K, Shimizu S, Kanno A, García-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y.
Diabetes. 2014 Sep;63(9):2996-3008. doi: 10.2337/db13-0970. Epub 2014 Apr 16